Introducing MASTCORE: Nutritional Support from AllerCore

25th October 2026

Some people living with mast cell activation syndrome find nutritional supplements a helpful addition to their usual care. If you have been exploring them, names like quercetin and luteolin may already be familiar. But knowing why an ingredient is in a supplement can be more useful than simply recognizing it on the label.

We are pleased to introduce MASTCORE, a mast cell support supplement developed by our own Dr. Maaz Mohiuddin through AllerCore Health. It combines quercetin phytosome, luteolin, buffered vitamin C, and bromelain in one formula. Here is a little about each.

Quercetin and luteolin

These are plant compounds called flavonoids, found in foods such as onions, apples, and celery. Scientists have studied them because of how they interact with mast cells, including the signals involved in releasing histamine. That is the connection behind their use in mast cell support supplements. Much of that research has been in lab-grown cells, rather than studies showing symptom relief in people with MCAS.

Quercetin also has an absorption problem: the body does not readily take it up in its ordinary form. MASTCORE uses Quercefit Quercetin Phytosome, which pairs it with phospholipids, a type of fat. A small study in healthy volunteers found better absorption with this type of formulation. That is useful to know when comparing labels, though it does not tell us how much difference someone will notice.

Buffered vitamin C

Vitamin C is best known as an everyday nutrient, but researchers have also explored its relationship with histamine levels. Those small studies are part of the reason it appears in supplements like this one, rather than proof of a benefit for MCAS.

The "buffered" part is about the form of vitamin C, not a higher strength. It is less acidic than plain ascorbic acid and is often chosen with stomach comfort in mind, although everyone's tolerance is different.

Bromelain

Bromelain comes from pineapple and is a mixture of enzymes that break down proteins. It has been studied for its role in inflammation more broadly; it is not an established MCAS treatment. If you have a pineapple allergy, its source is an important detail to discuss with your allergist before trying it.

Interested in trying a combined supplement?

We recommend AllerCore Health for patients interested in exploring this combination. MASTCORE brings the four ingredients into one bottle, rather than buying each separately. As with any supplement, the ingredient research is a starting point for a conversation, not a promise of results.

You can find the label and ordering details on the MASTCORE product page or through the supplement link in our navigation. Bring the label to your next appointment if you would like to talk it through. We can look at what you already take, check for overlapping ingredients and possible interactions, and discuss whether it is a sensible addition to your care. Your prescribed treatment and emergency plan should stay in place.

For more on symptoms, triggers, and evaluation, see our mast cell activation syndrome guide.